Observe Closely (three)pentobarbital will decrease the extent or influence of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Solid or moderate CYP3A4 inducers may well raise amount of diazepam elimination; thus, efficacy of diazepam may be lessened.pentobarbital will minimize the level or effect o